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New hope for tough blood cancers: experimental drug shows promise

NCT ID NCT03162536

First seen Nov 01, 2025 · Last updated Jun 17, 2026 · Updated 34 times

Summary

This study tests a new drug called ARQ 531 (nemtabrutinib) in about 190 people with blood cancers like lymphoma or leukemia that have returned or not responded to other treatments. The goal is to check the drug's safety and how well it works. Participants take the drug as a tablet, and researchers monitor side effects and tumor response.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Colorado Blood Cancer Institute ( Site 0225)

    Denver, Colorado, 80218, United States

  • Duke Cancer Center ( Site 0067)

    Durham, North Carolina, 27710, United States

  • Mayo Clinic - Rochester ( Site 0138)

    Rochester, Minnesota, 58905, United States

  • Mayo Clinic Hospital ( Site 0140)

    Scottsdale, Arizona, 85259, United States

  • Tennessee Oncology, PLLC ( Site 0020)

    Nashville, Tennessee, 37203, United States

  • The Ohio State University Wexner Medical Center ( Site 0056)

    Columbus, Ohio, 43210, United States

  • UCLA Hematology & Oncology ( Site 0017)

    Los Angeles, California, 90095, United States

  • UT Southwestern Medical Center ( Site 0116)

    Dallas, Texas, 75390-8562, United States

  • University of Michigan ( Site 0018)

    Ann Arbor, Michigan, 48109, United States

  • University of Utah, Huntsman Cancer Institute ( Site 0122)

    Salt Lake City, Utah, 84112, United States

Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia B-cell neoplasm B-cell non-Hodgkin lymphoma Blood Protein Disorders cardiovascular disorder diffuse large B-cell lymphoma follicular lymphoma hematopoietic and lymphoid system neoplasm hemorrhagic disease high grade B-cell lymphoma immune system disorder immunoproliferative disorder interdigitating dendritic cell sarcoma leukemia Leukemia, B-Cell lymphatic system disorder lymphoid leukemia lymphoma Lymphoma, B-Cell, Marginal Zone lymphoproliferative syndrome mantle cell lymphoma marginal zone lymphoma monoclonal gammopathy neoplasm Neoplasms by Histologic Type non-Hodgkin lymphoma plasma cell neoplasm Recurrence Richter transformation vascular disorder vascular hemostatic disease Waldenstrom macroglobulinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.