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Arginine before surgery may protect muscle in breast cancer patients

NCT ID NCT00497380

Disease control Sponsor: Texas A&M University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether giving arginine supplements to breast cancer patients before surgery could help prevent muscle breakdown and improve recovery. Researchers enrolled 19 women with breast cancer or those having preventive mastectomy. The goal was to see if arginine could normalize protein levels and reduce the negative effects of surgery on muscle.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

19 people

The number who actually took part.

Started

Aug 2009

Finished

Feb 2012

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Cancer groups (for aims 1 and 2) 1. Recently diagnosed (up to 4 weeks prior to treatment for cancer) with stage I, II or III invasive breast cancer 2. Undergoing mastectomy 3. Age greater than 30 years 4. Ability to sign informed consent 5. Good performance status defined by ECOG scale 0,1 or 2 (see CRF performance status) Control group (for aim 1) 1. Age greater than 30 years 2. Undergoing prophylactic mastectomy 3. Ability to sign informed consent 4. Good performance status defined by ECOG scale 0,1 or 2 (see CRF performance status) Exclusion Criteria: All groups (aim 1 and 2) 1. Body weight loss of greater than 10% in the past 3 months 2. Previous anti-cancer therapy (e.g. chemotherapy or radiotherapy) or surgery less than 4 weeks prior to the experiment 3. Diagnosed diabetes type I or II 4. Untreated metabolic diseases including liver or renal disease 5. Any documented autoimmune disease 6. Use of corticosteroids, beta-antagonists or nitrovasodilators 7. Use of supplements enriched with amino acids 8. Presence of acute illness or metabolically unstable chronic illness 9. Unstable heart disease requiring therapy or recent myocardial infarction (less than 1 year) 10. Current alcohol or drug abuse (ETOH more than 2 servings per day) 11. Allergy/intolerance to any of the ingredients of the study products 12. Any other condition deemed by the PI and the study physician as exclusion or that interferes with proper conduct of the study/ safety of the patient.

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Conditions

The condition(s) this trial relates to.

breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Protein metabolism

Contacts and locations

Locations

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, 72205, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.