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One-Shot gene therapy could replace monthly eye injections for wet AMD

NCT ID NCT07482176

Recruiting now Disease control Sponsor: Adverum Biotechnologies, Inc. Source: ClinicalTrials.gov ↗

First seen Mar 30, 2026 · Last updated May 21, 2026 · Updated 6 times

Summary

This Phase 3 trial tests a single injection of Ixo-vec gene therapy in 284 people with wet age-related macular degeneration (nAMD). The goal is to see if it can maintain or improve vision as well as standard aflibercept injections, but with fewer treatments needed. Participants receive either Ixo-vec or regular aflibercept injections, and vision is measured over a year.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Adverum Clinical Site 100

    RECRUITING

    Beverly Hills, California, 90211, United States

  • Adverum Clinical Site 107

    RECRUITING

    Conroe, Texas, 77384, United States

  • Adverum Clinical Site 109

    RECRUITING

    Bakersfield, California, 93309, United States

  • Adverum Clinical Site 116

    RECRUITING

    Denver, Colorado, 80207, United States

  • Adverum Clinical Site 124

    RECRUITING

    Deerfield Beach, Florida, 33064, United States

  • Adverum Clinical Site 126

    RECRUITING

    Phoenix, Arizona, 85014, United States

  • Adverum Clinical Site 127

    RECRUITING

    Austin, Texas, 78705, United States

  • Adverum Clinical Site 140

    RECRUITING

    Sacramento, California, 95825, United States

  • Adverum Clinical Site 162

    RECRUITING

    McAllen, Texas, 78503, United States

  • Adverum Clinical Site 165

    RECRUITING

    Waterford, Connecticut, 06385, United States

  • Adverum Clinical Site 169

    RECRUITING

    Fullerton, California, 92835, United States

  • Adverum Clinical Site 172

    RECRUITING

    Encino, California, 91436, United States

  • Adverum Clinical Site 176

    RECRUITING

    Fort Lauderdale, Florida, 33308, United States

  • Adverum Clinical Site 178

    RECRUITING

    Phoenix, Arizona, 85020, United States

  • Adverum Clinical Site 182

    RECRUITING

    Augusta, Georgia, 30909, United States

  • Adverum Clinical Site 183

    RECRUITING

    South Miami, Florida, 33143, United States

  • Adverum Clinical Site 184

    RECRUITING

    Deerfield Beach, Florida, 33064, United States

  • Adverum Clinical Site 189

    RECRUITING

    Walnut Creek, California, 94598, United States

  • Adverum Clinical Site 194

    RECRUITING

    Dallas, Texas, 75231, United States

  • Adverum Clinical Site 195

    RECRUITING

    Carmel, Indiana, 46032, United States

  • Adverum Clinical Site 196

    RECRUITING

    Asheville, North Carolina, 28803, United States

  • Adverum Clinical Site 198

    RECRUITING

    Springdale, Arkansas, 72764, United States

  • Adverum Clinical Site 199

    RECRUITING

    Lynchburg, Virginia, 24502, United States

  • Adverum Clinical Site 201

    RECRUITING

    Campbell, California, 95008, United States

  • Adverum Clinical Site 202

    RECRUITING

    Torrance, California, 90503, United States

  • Adverum Clinical Site 204

    RECRUITING

    Hagerstown, Maryland, 21740, United States

  • Adverum Clinical Site 209

    RECRUITING

    Wake Forest, North Carolina, 27587, United States

  • Adverum Clinical Site 211

    RECRUITING

    Greensboro, North Carolina, 27401, United States

  • Adverum Clinical Site 212

    RECRUITING

    Sacramento, California, 95841, United States

  • Adverum Clinical Site 213

    RECRUITING

    Orlando, Florida, 32806, United States

  • Adverum Clinical Site 214

    RECRUITING

    Lakeland, Florida, 33805, United States

  • Adverum Clinical Site 215

    RECRUITING

    Redlands, California, 92374, United States

  • Adverum Clinical Site 216

    RECRUITING

    Jackson, Mississippi, 39202, United States

  • Adverum Clinical Site 219

    RECRUITING

    Greensboro, North Carolina, 27401, United States

  • Adverum Clinical Site 220

    RECRUITING

    Hickory, North Carolina, 28602, United States

  • Adverum Clinical Site 221

    RECRUITING

    Fort Myers, Florida, 33912, United States

  • Adverum Clinical Site 222

    RECRUITING

    Ladson, South Carolina, 29456, United States

  • Adverum Clinical Site 223

    RECRUITING

    Phoenix, Arizona, 85020, United States

  • Adverum Clinical Site 224

    RECRUITING

    Huntington Beach, California, 92647, United States

  • Adverum Clinical Site 225

    RECRUITING

    Liverpool, New York, 13088, United States

  • Adverum Clinical Site 228

    RECRUITING

    Schertz, Texas, 78154, United States

  • Adverum Clinical Site 229

    RECRUITING

    Scottsdale, Arizona, 85255, United States

  • Adverum Clinical Site 231

    RECRUITING

    The Woodlands, Texas, 77384, United States

  • Adverum Clinical Site 232

    RECRUITING

    San Marcos, Texas, 78666, United States

  • Adverum Clinical Site 237

    RECRUITING

    Tyler, Texas, 75703, United States

  • Adverum Clinical Site 241

    RECRUITING

    Bluffton, South Carolina, 29910, United States

Conditions

Explore the condition pages connected to this study.

NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (NAMD) WET AMD