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Could an apple a day keep allergy symptoms away?

NCT ID NCT07380178

Symptom relief Sponsor: Universitas Sebelas Maret Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether apple fruit extract, which has antioxidant and anti-inflammatory properties, could improve symptoms of allergic rhinitis (hay fever). Forty adults with persistent allergies received either standard treatment plus apple extract or standard treatment alone. Researchers measured nasal symptoms and markers of inflammation and oxidative stress to see if the extract provided additional relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Apple fruit extract (Malus sylvestris mill) and quercetin
What this could lead to
If it works, this could point toward a natural supplement to ease nasal allergy symptoms.
What could go wrong
This is a small, completed study with only 40 participants. The results may not apply to everyone, and apple extract is not a replacement for standard allergy treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Apr 2025

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 - 60 years who have signed an informed consent * Diagnosed with persistent allergic rhinitis with a Skin Prick Test or Positive IgE Examination. Exclusion Criteria: * The presence of complications in the nose such as nasal septum deviation, polyps, rhinosinusitis * Have undergone specific immunotherapy for 2 years * Use of drugs that affect allergy test results: antihistamines, corticosteroids, antihypertensive drugs, and decongestants * Pregnancy and Breastfeeding

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Conditions

The condition(s) this trial relates to.

perennial allergic rhinitis Rhinitis, Allergic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rhinitis, allergic, perennial

Contacts and locations

Locations

  • Universitas Sebelas Maret Hospital

    Surakarta, Central Java, 57126, Indonesia