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New study: antioxidant SPF cream may shield skin DNA better than sunscreen alone

NCT ID NCT07301515

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a daily cream with antioxidants and SPF 50 protects skin DNA from sun damage better than a cream without these ingredients. Fifty-two healthy adults used the assigned cream on their face every day for 12 weeks. Researchers took cheek swabs at the start and end to measure DNA damage. The goal was to see if adding antioxidants to sunscreen offers extra protection against everyday sun exposure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

52 people

The number who actually took part.

Started

Mar 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-80 years * Healthy facial skin with no active dermatologic disease * Willing to apply the assigned product daily for 12 weeks * Willing to avoid additional facial skincare products during the study period * Able to attend baseline and week-12 visits for cheek-swab collection * Willing to maintain stable medication and supplement use throughout the study * Provided written informed consent Exclusion Criteria: * Active facial dermatologic disease or visible facial skin lesions * Laser, peel, or energy-based facial treatment within the past 3 months * Use of topical/systemic retinoids, antioxidants, or anti-inflammatory agents within 4 weeks of baseline * Pregnancy or breastfeeding * Recent acute illness or infection * Planned travel to high-UV or sunny destinations during the study period * Current smoker or regular e-cigarette user * Participation in another clinical trial within the previous 30 days * Known allergy or sensitivity to study-product ingredients * Unstable medical conditions or medications known to affect mitochondrial function (e.g., recent changes in antibiotics, statins, or thyroid medication)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • St John's Institute of Dermatology

    London, United Kingdom

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