New study: antioxidant SPF cream may shield skin DNA better than sunscreen alone
NCT ID NCT07301515
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a daily cream with antioxidants and SPF 50 protects skin DNA from sun damage better than a cream without these ingredients. Fifty-two healthy adults used the assigned cream on their face every day for 12 weeks. Researchers took cheek swabs at the start and end to measure DNA damage. The goal was to see if adding antioxidants to sunscreen offers extra protection against everyday sun exposure.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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52 people
The number who actually took part.
- Started
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Mar 2025
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 18-80 years * Healthy facial skin with no active dermatologic disease * Willing to apply the assigned product daily for 12 weeks * Willing to avoid additional facial skincare products during the study period * Able to attend baseline and week-12 visits for cheek-swab collection * Willing to maintain stable medication and supplement use throughout the study * Provided written informed consent Exclusion Criteria: * Active facial dermatologic disease or visible facial skin lesions * Laser, peel, or energy-based facial treatment within the past 3 months * Use of topical/systemic retinoids, antioxidants, or anti-inflammatory agents within 4 weeks of baseline * Pregnancy or breastfeeding * Recent acute illness or infection * Planned travel to high-UV or sunny destinations during the study period * Current smoker or regular e-cigarette user * Participation in another clinical trial within the previous 30 days * Known allergy or sensitivity to study-product ingredients * Unstable medical conditions or medications known to affect mitochondrial function (e.g., recent changes in antibiotics, statins, or thyroid medication)
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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St John's Institute of Dermatology
London, United Kingdom
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