Could common allergy pills reshape Kids' jawbones?
NCT ID NCT07752485
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This study investigates whether long-term use of H1 antihistamines (common allergy medications) is linked to changes in the jawbone structure of children aged 8 to 10. By analyzing dental X-rays, researchers will compare bone complexity and thickness in three groups: children on antihistamines, allergic children not on the medication, and healthy controls. The goal is to see if these medications might affect jawbone microarchitecture.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- H1 antihistamine (long-term use)
- What this could lead to
- If a link is found, it could inform dental monitoring for children on long-term allergy medications.
- What could go wrong
- This is a small, retrospective study, so it can only show associations, not cause and effect. Results may not apply broadly.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 84 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population will consist of children aged 8 to 10 years who attended the Department of Oral and Maxillofacial Radiology at Recep Tayyip Erdoğan University Faculty of Dentistry and had diagnostic-quality digital panoramic radiographs obtained as part of routine dental care. Participants will include children receiving long-term H1 antihistamine therapy, allergic children without antihistamine therapy, and age- and sex-matched healthy controls.
- Ages
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8 to 10 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * Children aged 8 to 10 years. * Availability of a diagnostic-quality digital panoramic radiograph obtained as part of routine dental care. * Presence of complete mandibular permanent first molars and permanent incisors. * Belonging to one of the following study groups: * Children receiving regular H1 antihistamine therapy for at least 12 months. * Children diagnosed with an allergic disease who have not received H1 antihistamine therapy during the previous 12 months. * Healthy children without allergic disease or long-term antihistamine use. * Availability of complete medical and dental records. Exclusion Criteria * History of systemic diseases or conditions known to affect bone metabolism. * Use of medications affecting bone metabolism (other than H1 antihistamines in the antihistamine group). * Craniofacial anomalies or syndromes. * History of orthodontic treatment. * Previous mandibular trauma or surgery. * Presence of radiographic pathology affecting the mandibular regions of interest (e.g., cysts, tumors, fractures, or extensive bone lesions). * Poor-quality panoramic radiographs with positioning errors or artifacts that interfere with image analysis. * Missing permanent first molars or incomplete eruption of teeth required for the analysis.
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How to take part
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The official record
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