Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Smart testing slashes antibiotic overuse in ER lung cases

NCT ID NCT05463406

Knowledge-focused Sponsor: Dr Boillat-Blanco Noemie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new way to decide if patients with lower respiratory tract infections need antibiotics. Instead of relying on standard methods, doctors used a step-by-step approach: a clinical score, a lung ultrasound, and a blood test for procalcitonin. The goal was to reduce unnecessary antibiotic prescriptions while keeping patients safe. Over 1,400 adults in Swiss emergency departments took part, and researchers compared the new approach to usual care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
diagnostic algorithm (clinical score, lung ultrasound, and procalcitonin blood test)
What this could lead to
If successful, this approach could help doctors prescribe antibiotics more accurately, reducing unnecessary use and slowing antibiotic resistance.
What could go wrong
The study is completed, but the strategy may not work for all patients or settings, and the diagnostic tests may not always correctly distinguish viral from bacterial infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,407 people

The number who actually took part.

Started

Dec 2022

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Signed informed consent * Patients aged 18 years or more * Acute LRTI (acute illness, less than 21 days, with at least one lower respiratory tract symptom, i.e. cough, sputum, dyspnea, chest pain and no alternative explanation) * At least one of the following clinical criteria: * Focal abnormal auscultation (decreased breath sounds, crackles, bronchial breath sounds) * Fever (documented temperature ≥ 38°C in the last 24 hours, including self-measured temperature ≥ 38°C) * Tachypnea (respiratory rate ≥ 22/minute) * Tachycardia (heart rate ≥ 100/minute) Exclusion Criteria: * Previous receipt of a quinolone, macrolide or ceftriaxone or, of more than one dose of any other antibiotic within 72h prior to enrolment (excepted prophylactic antibiotics or antibiotics given for urinary tract infection) * Previous hospital stay in the last 14 days * Cystic fibrosis * Severe COPD (≥GOLD 3 or if not available, as a proxy: exacerbation treated with antibiotics during the last 6 months) * Severe immunodeficiency (drug-induced neutropenia with \<500 neutrophils/mm3, HIV infection with CD4\<200 cells/mm3, solid organ or bone marrow transplant recipient, prednisone ≥ 20mg/day for \>28 days) * Initial admission of the patient in the intensive care unit * Microbiologically-documented SARS-CoV-2 * Incapacity of discernment

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Lower respiratory tract infection are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

lower respiratory tract disorder pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lower respiratory tract infection

Contacts and locations

Locations

  • Cantonal Hospital of St. Gallen

    Sankt Gallen, Canton of St. Gallen, 9007, Switzerland

  • Cantonal hospital of Baden

    Baden, Canton of Aargau, 5404, Switzerland

  • Centre hospitalier universitaire vaudois (CHUV)

    Lausanne, Canton of Vaud, 1011, Switzerland

  • Hôpital Intercantonal de la Broye

    Payerne, Canton of Vaud, 1530, Switzerland

  • Hôpital Riviera-Chablais

    Rennaz, Canton of Vaud, 1847, Switzerland

  • Kantonsspital Baselland

    Liestal, Canton of Basel-City, 4410, Switzerland

  • Luzerner Kantonsspital

    Lucerne, Canton of Lucerne, 6000, Switzerland

  • Réseau Hospitalier Neuchâtelois

    Neuchâtel, Canton of Neuchâtel, 2000, Switzerland

  • University Hospital of Basel

    Basel, Canton of Basel-City, 4031, Switzerland

More trials for these conditions

Other studies related to the condition(s) this trial covers.