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New antibiotic approach may cut infections after pancreatic surgery

NCT ID NCT07531420

Disease control Sponsor: Central Hospital, Nancy, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 117 patients who had pancreatic surgery to see if changing the antibiotic given before surgery could reduce infections. The researchers compared an older antibiotic (cephalosporin) with a newer one (piperacillin/tazobactam) based on local bacteria patterns. The goal was to find the best way to prevent surgical site infections while avoiding overuse of strong antibiotics.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
piperacillin/tazobactam (an antibiotic)
What this could lead to
If successful, this could help hospitals choose the best antibiotic to prevent infections after pancreatic surgery, reducing complications and the need for stronger antibiotics.
What could go wrong
This is a small, single-center study, so results may not apply to other hospitals. The infection risk depends on local bacteria, so the best antibiotic may vary by location.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

117 people

The number who actually took part.

Started

Jan 2022

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients undergoing pancreaticoduodenectomy for malignancy with preoperative biliary drainage at Nancy University Hospital between January 2022 and December 2025.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (\> 18 yrs) * Scheduled for pancreatic surgery * Presence of preoperative biliary stent * Postoperative admission to surgical ICU or intermediate care unit Exclusion Criteria: * decline to participate

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Conditions

The condition(s) this trial relates to.

Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Antibiotic prophylaxis Pancreatic surgery Surgical site infection (SSI) Surgical site infection prevention

Contacts and locations

Locations

  • University Hospital of Nancy

    Nancy, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.