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ICU antibiotic levels under the microscope

NCT ID NCT01543334

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nīmes Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether antibiotics given to critically ill patients reach high enough levels in the blood to kill bacteria. Researchers measured drug concentrations in 98 ICU patients and compared them to targets known to be effective. The goal was to understand dosing, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

98 people

The number who actually took part.

Start date

Mar 2012

Finished

Apr 2012

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Intensive care patients with a vein or artery catheter and who are being administered antibiotics Can be of the following: Amoxicillin-clavulanic acid, ampicillin, piperacillin-tazobactam, penicillin G, flucloxacillin, dicloxacillin, cloxacillin, cefazolin, ceftazidime, ceftriaxone, cefepime, meropenem, imipenem, doripenem, ertapenem; Vancomycin, teicoplanin.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The patient (or his/her "trusted representative") must have given his/her informed and signed consent * Antibiotic treatment is administered with beta-lactams or glycopeptides administered continuously or intermittently (Can be of the following: Amoxicillin-clavulanic acid, ampicillin, piperacillin-tazobactam, penicillin G, flucloxacillin, dicloxacillin, cloxacillin, cefazolin, ceftazidime, ceftriaxone, cefepime, meropenem, imipenem, doripenem, ertapenem; Vancomycin, teicoplanin). * A vein or artery catheter is established to facilitate blood sampling (arterial catheter is preferred) Exclusion Criteria: * None of the above-mentioned antibiotics are administered * Impossible to establish venous or arterial catheter * Consent not given * Patient is pregnant, parturient or breastfeeding * The patient is under tutorship or curatorship * The patient is participating in another study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Administration of antibiotics in intensive care units

Contacts and locations

Locations

  • APHM - Hôpital Nord

    Marseille, 13915, France

  • APHP - Hôpital Bichat - Claude Bernard

    Paris, 75877, France

  • CH du Pays d'Aix

    Aix-en-Provence, 13616, France

  • CHRU de Strasbourg - Hôpital Civil

    Strasbourg, 67091, France

  • CHU d'Amiens - Hôpital Nord

    Amiens, 80054, France

  • CHU d'Angers - Hôtel-Dieu

    Angers, 49933, France

  • CHU de Bordeaux - Hôpital Haut-Lévêque

    Pessac, 33604, France

  • CHU de Clermont Ferrand - Hôpital Estaing

    Clermont-Ferrand, 63003, France

  • CHU de Grenoble - Hôpital A Michallon

    Grenoble, 38043, France

  • CHU de Montpellier - Hôpital Saint-Eloi

    Montpellier, 34295, France

  • CHU de Nice - Hôpital St-Roch

    Nice, 06006, France

  • CHU de Nîmes - Hôpital Universitaire Carémeau

    Nîmes, 30029, France

  • CHU de Rennes - Hôpital PontChaillou

    Rennes, 35033, France