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Does anesthesia flow affect brain pressure during surgery?

NCT ID NCT07514026

Knowledge-focused Sponsor: Bursa City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how different anesthesia gas flows affect brain pressure and oxygen levels in women having laparoscopic hysterectomy. 64 women were randomly assigned to either high-flow or low-flow anesthesia. The researchers measured brain pressure indirectly using eye ultrasound and brain oxygen using a forehead sensor. The goal was to see if one method is safer for the brain during this type of surgery.

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Study facts

What this study's own registry entry says, in plain language.

Participants

64 people

The number who actually took part.

Started

Jan 2024

Finished

Jun 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

According to the study, 64 female patients aged between 18 and 75 who were to undergo laparoscopic hysterectomy were included, all of whom were classified as Class I or II according to the American Society of Anesthesiologists (ASA) physical status.

Ages

18 to 75 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Female patients aged 18-75 years * Scheduled for elective laparoscopic hysterectomy * American Society of Anesthesiologists (ASA) physical status I-II * Ability to provide written informed consent Exclusion Criteria * Septicemia * Risk of malignant hyperthermia * Uncontrolled diabetes mellitus * Chronic alcohol use * Prolonged fasting * Body mass index (BMI) \> 40 kg/m² * Intracranial space-occupying lesions (e.g., tumors, metastases, abscesses, hematomas, aneurysms) * History of head trauma or cerebrovascular stroke within the preceding six months * Known heart failure * Diagnosis of glaucoma * Prior carotid surgery or carotid artery stenosis * ASA physical status ≥ III * Requirement for massive blood transfusion * Conversion from volume-controlled to pressure-controlled mechanical ventilation during surgery * Intraoperative conversion to open surgery * Patient refusal to participate

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebral oxygenation Low flow anesthesia Optic nerve sheath diameter measurement

Contacts and locations

Locations

  • Bursa City Hospital

    Bursa, 16110, Turkey (Türkiye)

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