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New hope for advanced liver cancer: targeted drug trial launches

NCT ID NCT06600321

First seen Oct 31, 2025 · Last updated May 23, 2026 · Updated 30 times

Summary

This early-stage study tests a new drug called ALN-BCAT, given alone or with an immunotherapy (pembrolizumab), in people with advanced liver cancer that has spread. The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. About 158 adults whose cancer has a specific gene change (WNT pathway mutation) and who have already tried at least one other treatment can join.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Clinical Trial Site

    RECRUITING

    Phoenix, Arizona, 85054, United States

  • Clinical Trial Site

    RECRUITING

    La Jolla, California, 92037, United States

  • Clinical Trial Site

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    Los Angeles, California, 90033, United States

  • Clinical Trial Site

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    Jacksonville, Florida, 32224, United States

  • Clinical Trial Site

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    Atlanta, Georgia, 30322, United States

  • Clinical Trial Site

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    Chicago, Illinois, 60637, United States

  • Clinical Trial Site

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    Ann Arbor, Michigan, 48109, United States

  • Clinical Trial Site

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    Rochester, Minnesota, 55905, United States

  • Clinical Trial Site

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    New York, New York, 10029, United States

  • Clinical Trial Site

    RECRUITING

    New York, New York, 10032, United States

  • Clinical Trial Site

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    Cleveland, Ohio, 44106, United States

  • Clinical Trial Site

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • Clinical Trial Site

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    Dallas, Texas, 75390, United States

  • Clinical Trial Site

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    Houston, Texas, 77030, United States

  • Clinical Trial Site

    RECRUITING

    San Antonio, Texas, 78229, United States

  • Clinical Trial Site

    RECRUITING

    Richmond, Virginia, 23298, United States

  • Clinical Trial Site

    RECRUITING

    Milan, 20132, Italy

  • Clinical Trial Site

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    Rozzano, 20089, Italy

  • Clinical Trial Site

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    Verona, 37134, Italy

  • Clinical Trial Site

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    Busan, 49241, South Korea

  • Clinical Trial Site

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    Seongnam, 13496, South Korea

  • Clinical Trial Site

    RECRUITING

    Seongnam, 13620, South Korea

  • Clinical Trial Site

    RECRUITING

    Seoul, 03722, South Korea

Conditions

Explore the condition pages connected to this study.