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Which nasal spray works best for hay fever? new study compares two options

NCT ID NCT07415278

Symptom relief Sponsor: Pamukkale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two nasal sprays for moderate-to-severe allergic rhinitis (hay fever): fluticasone alone versus a combination of fluticasone and azelastine. Researchers will track symptom relief and quality of life in 61 adults over two months to see which spray works better and faster.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fluticasone propionate and azelastine hydrochloride nasal sprays
What this could lead to
If the combination spray works better, it could offer a more effective first-line option for people with moderate-to-severe allergic rhinitis.
What could go wrong
This is a small, phase 4 study with only 61 participants, so results may not apply to everyone. The difference between the two sprays might be small or not meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

61 people

The number who actually took part.

Started

Dec 2022

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years and older * Clinical symptoms consistent with allergic rhinitis * Positive skin prick test results * Moderate-to-severe allergic rhinitis defined as a Score for Allergic Rhinitis (SFAR) of 7 or higher * Willingness to participate and provide informed consent Exclusion Criteria: * Patients under 18 years of age * Patients with atopic diseases (e.g., atopic dermatitis) or asthma, other than allergic rhinitis * Those with a recent respiratory tract infection, nasal polyps, or septal deviation * Patients who had previously undergone sinonasal surgical treatment * Individuals who use tobacco, alcohol, or illicit drugs * Those who have used the following medications: Antihistamines (within the last week) Nasal or oral decongestants (within the last week) Topical corticosteroids (within the last 2 weeks) Membrane stabilizers (within the last 2 weeks) Leukotriene antagonists (within the last 2 weeks) Systemic corticosteroids (past 4 weeks) Immunotherapy (within the past 5 years) • Patients with allergic rhinitis symptom score \<7

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Conditions

The condition(s) this trial relates to.

allergic rhinitis Rhinitis, Allergic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Allergic rhinitis

Contacts and locations

Locations

  • Pamukkale University

    Denizli, Pamukkale, 20070, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.