New study tailors amyloidosis therapy based on genetic marker
NCT ID NCT06192979
First seen Mar 14, 2026 · Last updated May 21, 2026 · Updated 9 times
Summary
This study aims to improve initial treatment for people with systemic light chain (AL) amyloidosis who have a specific genetic change called t(11;14). All 41 participants will start with a standard drug combination (daratumumab, bortezomib, and dexamethasone). If their blood responds quickly within 7 days, they continue that regimen; if not, they switch to a different combination including venetoclax. The goal is to achieve a complete blood response within 6 months and improve organ function.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beijing Anzhen Hospital
RECRUITINGBeijing, Beijing Municipality, 101118, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Capital Medical University Affiliated Fuxing Hospital
RECRUITINGBeijing, Beijing Municipality, 100045, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chinese PLA Eastern Theater General Hospital
RECRUITINGNanjing, Jiangsu, 210000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Peking University People's Hospital
RECRUITINGBeijing, Beijing Municipality, 100044, China
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Qingdao Municipal Hospital
RECRUITINGQingdao, Shandong, 266011, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Xi'an Jiao Tong University
RECRUITINGXi’an, Shanxi, 710061, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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