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Massive farm study tracks Pesticide-Cancer links for decades

NCT ID NCT00352924

Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 17, 2026 · Updated 19 times

Summary

This study follows nearly 90,000 farmers, their spouses, and pest control workers in Iowa and North Carolina over many years. Researchers track their exposure to pesticides and other farm chemicals, then monitor who develops cancer or other diseases. The goal is to identify which exposures are most harmful, so future cancers can be prevented.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could identify which pesticides and farming practices increase cancer risk, helping to prevent future cases.
What could go wrong
This is an observational study, not a treatment trial. It can show links but not prove cause and effect. Results may take many more years to emerge.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

89,655 people

The number who actually took part.

Start date

Apr 1993

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

A prospective cohort of 89,655 registered pesticide applicators and spouses (57,310 applicators and 32,346 spouses of private applicators) with sufficient personal identifiers to conduct follow up activities has been assembled during the first four years of recruitment in the Agricultural Health Study, 1993-1997. The majority of applicators were asked to enroll in the AHS as they obtained or renewed their pesticide registration/licenses through the agricultural extension services of the states of North Carolina and Iowa. In the last year of enrollment, applicators who received or renewed their pesticide licenses, but were never given the opportunity to enroll due to added requirements in the testing/training class, were called and asked to complete the enrollment questionnaire over the phone. Spouses of the private applicators were also given the opportunity to enroll via the telephone.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: All registered pesticide applicators in Iowa and North Carolina and the spouse and children of applicators who are farmers.

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Conditions

The condition(s) this trial relates to.

lymphoma neoplasm plasma cell myeloma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lymphoma Multiple myeloma Pesticide exposures Prostate cancer

Contacts and locations

Locations

  • Research Triangle Institute

    Research Triangle Park, North Carolina, 27709, United States

More trials for these conditions

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