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Exercise plus brain zaps: a new pain relief combo?

NCT ID NCT07058584

Knowledge-focused Sponsor: Aalborg University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether combining 30 minutes of stationary biking with a non-invasive brain stimulation technique (repetitive transcranial magnetic stimulation, or rTMS) changes how the brain connects and how sensitive people are to pain. Twenty healthy adults attended two sessions—one with real rTMS and one with a sham (fake) version—to compare effects. The goal was to understand the brain mechanisms behind this combination, not to treat any condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could point toward new ways to manage pain by combining exercise with brain stimulation.
What could go wrong
This is a small, early-stage study in healthy volunteers, so results may not apply to people with chronic pain. The effects are measured in the lab, not in real-world settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Apr 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy men and women aged 18-60 years * Speak and understand English Exclusion Criteria: * Pregnant or breastfeeding * Regular use of cannabis, opioids, or other drugs * Chronic pain (i.e., pain most days within the last three months) * Current or previous neurologic or musculoskeletal illnesses, psychiatric diagnoses, or other ilnesses (e.g., brain or spinal cord injuries, degenerative neurological disorders, major depression, cardiovascular disease, chronic lung disease, etc.) * Current regular use of analgesic medication or other medication which may affect the trial (including paracetamol and NSAIDs) * Recent history of acute pain (i.e., episodic migraine attacks or pain in the lower limbs) * Abnormally disrupted sleep in 24 hours preceding experiment * Contraindications to TMS application (history of epilepsy, metal implants in head or jaw, etc.) * Unable to fulfil the criteria of the "Transcranial Magnetic Stimulation Adult Safety Screen" * Presence of implanted hearing aids or metal implants on the face, including permanent makeup or tattoos. * Lack of ability to cooperate

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aerobic exercise Repetitive transcranial magnetic stimulation (RTMS)

Contacts and locations

Locations

  • Aalborg University

    Gistrup, 9260, Denmark

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