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Simple toothbrushing may cut ventilator pneumonia risk

NCT ID NCT06039995

Prevention Sponsor: University of Health Sciences Lahore Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study tested whether adding toothbrushing and oral gel to standard chlorhexidine mouthwash could prevent ventilator-associated pneumonia (VAP) in 100 ICU patients. The intervention group received comprehensive oral care, while the control group got mouthwash alone. Researchers measured VAP rates, ICU stay length, and mortality to see if the extra steps made a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Chlorhexidine mouthwash, toothbrushing, and oral gel
What this could lead to
If effective, this simple oral care routine could become a standard way to prevent pneumonia in ICU patients on ventilators.
What could go wrong
This is a small, single-center trial with 100 patients, so results may not apply to all ICU settings. The intervention adds steps to care without strong proof yet.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

100 people

The number who actually took part.

Started

Aug 2024

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ICU patients on intensive mechanical ventilation aged 18-65 years of either sex with oral ETT in situ. * MCPIS score between 0 to 5 on first day of admission at ICU Exclusion Criteria: * More than 48 hours of mechanical ventilation before ICU admission. * Previous history of respiratory illness. * Immunocompromised. * Ongoing sepsis. * Pregnancy. * Presence of dentures.

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Conditions

The condition(s) this trial relates to.

pneumonia Pneumonia, Ventilator-Associated

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pneumonia, ventilator-associated

Contacts and locations

Locations

  • Services Hospital

    Lahore, Pakistan

  • University of Health Sciences

    Lahore, Punjab Province, 54000, Pakistan

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