Smart scans may sharpen radiation for lung cancer
NCT ID NCT01507428
First seen Apr 23, 2026 · Last updated Jun 22, 2026 · Updated 8 times
Summary
This study tested whether using PET/CT scans during treatment to adjust radiation plans can improve outcomes for people with stage III non-small cell lung cancer. 138 participants were randomly assigned to receive either standard radiation or radiation guided by mid-treatment scans. The goal was to see if this personalized approach could better control tumors while reducing damage to healthy tissue.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Augusta University Medical Center
Augusta, Georgia, 30912, United States
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Case Western Reserve University
Cleveland, Ohio, 44106, United States
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Cleveland Clinic Cancer Center Independence
Independence, Ohio, 44131, United States
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Cleveland Clinic Cancer Center Strongsville
Strongsville, Ohio, 44136, United States
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Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio, 44111, United States
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio, 44691, United States
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio, 44124, United States
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Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202, United States
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McGill University Department of Oncology
Montreal, Quebec, H2W 1S6, Canada
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack
Commack, New York, 11725, United States
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Memorial Sloan Kettering Nassau
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Sleepy Hollow
Sleepy Hollow, New York, 10591, United States
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Memorial Sloan Kettering Westchester
Harrison, New York, 10604, United States
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Reading Hospital
West Reading, Pennsylvania, 19611, United States
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Rush University Medical Center
Chicago, Illinois, 60612, United States
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Saint Luke's Hospital of Kansas City
Kansas City, Missouri, 64111, United States
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Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4, Canada
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Stanford Cancer Institute Palo Alto
Palo Alto, California, 94304, United States
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Temple University Hospital
Philadelphia, Pennsylvania, 19140, United States
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The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, 40202, United States
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University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109, United States
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University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
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University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, 53792, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
radiation therapy guided by PET/CT scans
What this could lead to
If successful, this approach could allow doctors to deliver higher, more effective radiation doses to tumors while sparing healthy tissue, potentially improving local control of lung cancer.
What could go wrong
This is a phase 2 trial with only 138 participants, so results are preliminary. The benefit over standard radiation is not yet proven, and there may be risks from higher radiation doses.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.