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Could a placenta injection heal stubborn achilles pain?

NCT ID NCT06172218

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a special injection made from donated placenta tissue in 20 people with long-lasting Achilles tendon pain that didn't get better with standard treatments like physical therapy. The goal was to see if the injection could reduce pain and improve function. Results will help design a larger study.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Nov 2023

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 64 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18 to 64 years old 2. BMI ≤ 40 kg/m2 3. Subject has been diagnosed with unilateral Achilles tendinopathy (based on investigator assessment using ultrasound) of at least 3 months duration 4. History of having attempted a physical therapy for Achilles tendinopathy which must have included at least 6 weeks of eccentric exercise, alone or in addition to other non-surgical therapies 5. VISA-A score for the target tendon ≥40 and ≤60 at screening 6. Subject is willing to comply with all study procedures 7. Willing to sign a written informed consent to participate 8. Able to follow study instructions, with the intention of completing all required visits Exclusion Criteria: 1. Planned surgical procedure below knee of the targeted extremity during study period 2. Patient has previously received an injection for this injury within the past 2 months 3. Major lower limb amputation of the contralateral leg 4. A medical condition, or a personal situation, which in the principal investigator's opinion, is not appropriate for participation in the trial 5. Osteoarthritis, chronic low back pain, fibromyalgia or any other condition that may affect the responses on the VISA-A 6. HIV infection, Hepatitis B or C infection, tuberculosis, COVID-19, cellulitis or any other active infection 7. Cognitive impairment, mental illness, neuroses, or untreated depression that would preclude understanding or reliably completing the patient reported outcome measures 8. Peritendinopathy, paratenonitis, partial tear or tendon rupture of the affected tendon 9. Subject has hindfoot deformities on the targeted extremity 10. Plantar fasciitis, calcaneal bursitis, Sever's disease, retrocalcaneal exostosis (Mulholland deformity, Haglund's deformity), enthesophytes, myofascial pain referral, posterior ankle impingement, os trigonum syndrome, tenosynovitis or dislocation of the peroneal or other plantar flexor tendons, an accessory soleus muscle, irritation or neuroma of the sural nerve, or systemic inflammatory disease 11. Leg length discrepancy, hyperpronation, varus deformity of the forefoot, pes cavus or limited mobility of the subtalar joint 12. Prior surgical intervention to the affected tendon 13. Current use of vitamins or herbal supplements 14. Current use of opioids, midazolam, gabapentin, pregabalin or ketamine 15. Compensable disability or work injury, ongoing litigation, or ongoing chiropractic care 16. Current use of systemic immunosuppressive medications, chemotherapy, or history of organ transplant (kidney, heart, lung) 17. Pregnancy and women who are expecting to be pregnant 18. Current enrollment in another interventional drug or device study or participation in such a study within 30 days of anticipated entry into this study

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • North Park Podiatry

    San Diego, California, 92104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.