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10,000 patients join hunt to tame deadly inflammation after aortic tear

NCT ID NCT04398992

Knowledge-focused Sponsor: Nanjing Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This registry follows 10,000 adults who had surgery for acute aortic syndrome, a life-threatening condition. Researchers are tracking how inflammation affects recovery and long-term outcomes. The goal is to find better ways to manage inflammation and improve survival.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this registry could reveal which anti-inflammatory strategies improve survival and reduce complications after aortic surgery.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 10,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2016

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Chinese patients suffering AAS

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria * Aged 18 years or older. * Patients with diagnosis of AAS, including aortic dissection, penetrating aortic ulcer or intramural hematoma. * Symptoms started within 14 days from surgery. * Patients received medical therapy, open surgical, endovascular, or hybrid repair. * Any other major cardiac surgical procedure concomitant with surgery for AAS, such as coronary artery bypass grafting or carotid artery replacement; * The patient or guardian agrees to participate in this study. Exclusion criteria * Patients aged \< 18 years. * Onset of symptoms \> 14 days from surgery. * AAS secondary to traumatic or iatrogenic injury. * Patients who declined participation in registration and follow-up investigation.

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Conditions

The condition(s) this trial relates to.

Acute Aortic Syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute aortic syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    30 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beijing Anzhen Hospital Capital Medical University

    RECRUITING

    Beijing, China

  • Beijing Chaoyang Hospital

    RECRUITING

    Beijing, China

  • Beijing Fuwai Hospital Chinese Academy of Medical Sciences

    RECRUITING

    Beijing, Beijing Municipality, China

  • Chongqing Hospital of Jiangsu Provincial People's Hospital

    RECRUITING

    Chongqing, Chongqing Municipality, China

  • Dongtai People's Hospital

    RECRUITING

    Yancheng, Jiangsu, China

  • Guangdong Provincial People's Hospital

    RECRUITING

    Guangzhou, Guangdong, China

  • Nanjing First Hospital, Nanjing Medical University

    RECRUITING

    Nanjing, China

  • QianXiNan People's Hospital

    RECRUITING

    Xingyi, Guizhou, China

  • Qilu Hospital of Shandong University

    RECRUITING

    Jinan, Shandong, 250012, China

  • Shanghai DeltaHealth Hospital

    RECRUITING

    Shanghai, Shanghai Municipality, China

  • Shanghai East Hospital Tongji University

    COMPLETED

    Shanghai, China

  • Shanxi Cardiovascular Hospital

    RECRUITING

    Taiyuan, Shanxi, China

  • Subei People's Hospital of Jiangsu Province

    RECRUITING

    Yangzhou, Jiangsu, 225001, China

  • Suqian Hospital of of Nanjing Medical University

    RECRUITING

    Suqian, Jiangsu, China

  • Teda International Cardiovascular Hospital

    RECRUITING

    Tianjin, China

  • The First Affiliated Hospital of Guangxi Medical University

    RECRUITING

    Nanning, Guangxi, China

  • The First Affiliated Hospital of Guangzhou Medical University

    RECRUITING

    Guangzhou, China

  • The First Affiliated Hospital of Kunming Medical University

    RECRUITING

    Kunming, Yunnan, China

  • The First Affiliated Hospital of Nanjing Medical University

    RECRUITING

    Nanjing, 210029, China

  • The First Affiliated Hospital of Wenzhou Medical University

    RECRUITING

    Wenzhou, Zhejiang, China

  • The Friendship Hospital of Yili Kazak Autonomous Prefecture

    RECRUITING

    Yining, Xinjiang, China

  • The Second Affiliated Hospital of Harbin Medical University

    RECRUITING

    Harbin, Heilongjiang, China

  • The Seventh Affiliated Hospital of Xinjiang Medical University

    RECRUITING

    Ürümqi, Xinjiang, China

  • The Third Affiliated Hospital of Soochow University

    RECRUITING

    Changzhou, Jiangsu, China

  • Tianjin Chest Hospital

    RECRUITING

    Tianjin, China

  • West China Hospital of Sichuan University

    RECRUITING

    Chengdu, Sichuan, China

  • Xiamen Cardiovascular Hospital

    COMPLETED

    Xiamen, China

  • Xiangya Hospital Central South University

    COMPLETED

    Changsha, China

  • Zhejiang Provincial People's Hospital

    RECRUITING

    Hangzhou, Zhejiang, China

  • the Affiliated Hospital of Qingdao University

    COMPLETED

    Qingdao, China

  • the First Affiliated Hospital of Bengbu Medical College

    RECRUITING

    Bengbu, China

  • the First Affiliated Hospital of Guilin Medical College

    RECRUITING

    Guilin, China

  • the First Affiliated Hospital of Shantou University Medical College

    RECRUITING

    Shantou, China

  • the Second Affiliated Hospital of Nanchang University

    RECRUITING

    Nanchang, Jiangxi, 300088, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.