Alimentiv Inc.

This study tests whether treating Crohn's disease to a target of full gut wall healing (transmural healing) is better than treating symptoms alone. About 304 adults with moderate-to-severe Crohn's will be randomly assigned to one of two treatment strategies over 48 weeks. One gro…

This study includes about 50 adults with Crohn's disease who have a permanent ileostomy. Researchers will review routine endoscopy videos and interview participants to create new tools that measure inflammation and symptoms. The goal is to help include this group in future clinic…

This study watches 300 adults with Crohn's disease who are starting vedolizumab or an IL-23 blocker for the first time. Researchers will track how quickly patients feel improvements in pain, fatigue, mood, and daily activities using simple questionnaires. The goal is to learn whe…

This study tests whether using a blood test that looks at epigenetic markers can help doctors choose the best biologic drug for people with active Crohn's disease. About 378 adults will be randomly assigned to either have their treatment chosen by this test or by the usual doctor…