Sickle cell disease (SCD)

This trial asks whether using a pharmacokinetic test—which tracks how the body absorbs and processes a drug—can help children with sickle cell disease reach the best dose of hydroxyurea faster than the usual bloodwork checks. Patients are split into groups: one gets dose adjustme…

This study tests whether the birth control shot Depo-Provera can reduce painful sickle cell episodes in women. Sixty-five women with sickle cell disease who have frequent pain will be monitored for 3 months without the shot, then for 3 months after receiving it. Researchers will …

Researchers at Ain Shams University in Cairo are creating a registry to track children, adolescents, and young adults with sickle cell disease. The goal is to collect detailed clinical data over time to better understand the disease and improve patient management. This study does…

This large study will follow 480 children with sickle cell disease to compare two treatment approaches: a stem cell transplant from a matched family donor versus standard disease-modifying therapies. The goal is to see which option leads to better quality of life and thinking ski…

This study is building a special collection of blood and urine samples from 800 adults with sickle cell disease or sickle cell trait, along with some healthy volunteers. Researchers will use these samples and medical records to learn how kidney disease starts and gets worse in pe…