SCLERODERMA, SYSTEMIC

This study tests whether the drug belimumab can improve lung function and reduce skin thickening in adults with systemic sclerosis (scleroderma) that has caused lung scarring. About 300 participants will receive either belimumab or a placebo, added to their usual care. The main g…

This study tests whether diosmin, a citrus-based supplement, can safely heal open sores on the fingers (digital ulcers) in people with scleroderma. About 45 adults with at least one active ulcer will receive either diosmin or a placebo for 8 weeks. Researchers will track ulcer he…

This study tests a biopsychosocial exercise program called BETY in 48 children and adults with scleroderma. The goal is to see if it improves physical function, skin health, and overall well-being. Participants are randomly assigned to BETY or standard care, and outcomes are meas…

This study explores whether a simple, noninvasive scalp exam called trichoscopy can help evaluate people with systemic scleroderma. Researchers will compare scalp images from 200 patients and healthy volunteers to see if certain features relate to organ damage or overall disease …

This study aims to uncover the key factors that cause and worsen systemic sclerosis (scleroderma), a serious autoimmune disease that hardens the skin and can damage organs like the lungs. Researchers will collect blood and skin samples from 150 patients in Sweden to look for gene…