PMMR/MSS locally advanced rectal cancer
Clinical trials for PMMR/MSS locally advanced rectal cancer explained in plain language.
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Triple threat: immunotherapy, chemo, and radiation take on rectal cancer
Disease control Recruiting nowThis phase 2 trial is testing whether adding an immunotherapy drug (adebrelimab) to a chemotherapy combo (NALIRIFOX) and radiation can improve outcomes for people with a certain type of locally advanced rectal cancer (pMMR/MSS). About 84 participants will be randomly assigned to …
Matched conditions: PMMR/MSS LOCALLY ADVANCED RECTAL CANCER
Phase 2 • Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
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New combo therapy aims to outsmart 'Cold' rectal tumors
Disease control Recruiting nowThis Phase II trial tests whether adding a dual immunotherapy drug (iparomlimab/tuvonralimab) to standard chemoradiotherapy can improve outcomes for patients with locally advanced rectal cancer that has a specific genetic profile (pMMR/MSS), which usually does not respond to immu…
Matched conditions: PMMR/MSS LOCALLY ADVANCED RECTAL CANCER
Phase 2 • Sponsor: Shandong Cancer Hospital and Institute • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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Immunotherapy combo shows promise in Hard-to-Treat rectal cancer
Disease control Recruiting nowThis phase 2 trial tests whether adding an immunotherapy drug (PD-1 antibody) and a blood vessel blocker (bevacizumab) to standard short-course radiotherapy and chemotherapy can improve outcomes for people with a common type of locally advanced rectal cancer (pMMR/MSS). About 86 …
Matched conditions: PMMR/MSS LOCALLY ADVANCED RECTAL CANCER
Phase 2 • Sponsor: Dechang Diao • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC