Mitral valve regurgitation

This study tests a new device to replace the mitral valve in people with severe mitral regurgitation (a leaky heart valve) who cannot have standard surgery or a less invasive repair. About 1,056 participants will receive the device and be followed for safety and quality of life. …

This trial is testing a new device called the AltaValve System, which is placed inside the heart to replace a leaky mitral valve. The study includes adults with moderate-to-severe mitral regurgitation who are not suitable for surgery or a less invasive repair procedure. The goal …

This study tests whether giving two steroids (hydrocortisone and fludrocortisone) to high-risk patients before heart surgery can lower the chance of serious complications like kidney injury and lung problems. The trial will include 196 adults with a EuroSCORE II above 4% who are …

This study will collect information from 15 patients in Asia-Pacific who have had or will have a less invasive procedure to fix a failed mitral or tricuspid heart valve. The goal is to learn how well these procedures work in this population, since most existing data comes from We…

This registry tracks the safety and real-world outcomes of a minimally invasive procedure to repair a leaky mitral valve (mitral regurgitation) using a device called a leaflet clip. It will enroll up to 4,000 patients across many hospitals. The goal is to monitor adverse events a…

This study watches 150 adults with heart valve problems who are getting a procedure (TAVI or M-TEER) to see if it helps their sleep-disordered breathing. Participants take a sleep test before the procedure and again 6 months later. The goal is to learn how fixing heart valves mig…

This study uses artificial intelligence to analyze data from 21,000 patients who had heart valve procedures. The goal is to make AI tools that can predict surgery outcomes, like which device to use and risks of complications, with over 90% accuracy. This is a non-interventional s…