Leptomeningeal disease (LMD)
Clinical trials for Leptomeningeal disease (LMD) explained in plain language.
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Can a CXCR1/2 blocker boost radiation against cancer that spreads to the brain lining?
Disease control Recruiting nowResearchers are testing whether combining SX-682, an experimental drug that blocks CXCR1 and CXCR2, with proton craniospinal irradiation is safe and effective for people with leptomeningeal disease from melanoma or non-small cell lung cancer. Participants take SX-682 by mouth twi…
Matched conditions: LEPTOMENINGEAL DISEASE (LMD)
Phase 1 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Spinal tap could spot hidden brain cancers
Knowledge-focused Recruiting nowThis pilot study is exploring whether a one-time sample of spinal fluid (taken via a lumbar puncture) can detect cancer DNA in patients with solid tumors that have spread to the brain or spinal cord. Researchers will enroll 60 participants across three groups: those with leptomen…
Matched conditions: LEPTOMENINGEAL DISEASE (LMD)
Sponsor: Sunnybrook Health Sciences Centre • Aim: Knowledge-focused
Last updated Aug 02, 2026 00:00 UTC