LARGE B-CELL LYMPHOMA (LBCL)

This early-stage trial tests whether adding a drug called CLS-015 to standard CAR-T cell therapy can help people with large B-cell lymphoma whose disease is stable or getting worse. CLS-015 works by breaking down NETs, which are immune-trapping webs that may block CAR-T cells. Th…

This study tests a treatment called CD19 CAR-T therapy for people newly diagnosed with a fast-growing type of blood cancer called high-risk large B-cell lymphoma. The therapy uses a patient's own immune cells, modified to better attack cancer cells. The main goal is to see how ma…

This study is testing a more affordable version of CAR-T cell therapy for people with relapsed or hard-to-treat large B-cell lymphoma. The treatment uses the patient's own immune cells, modified to attack cancer cells. The goal is to see if this academic-made therapy works as wel…

This study tests a new drug called surovatamig (AZD0486) in adults with B-cell non-Hodgkin lymphoma that has come back or stopped responding to at least two prior treatments. The goal is to see if the drug can shrink or eliminate tumors. About 240 participants will receive the dr…

This study tests a combination of four drugs (Pola-ZR-Glo) in older adults (70+) newly diagnosed with large B-cell lymphoma who cannot tolerate standard chemotherapy. The goal is to control the disease and improve quality of life. About 30 participants will receive the treatment …