Interstitial lung diseases

This study tests whether the drug nerandomilast can slow lung scarring in people with autoimmune diseases like rheumatoid arthritis or scleroderma. About 400 adults whose lung function hasn't improved with standard treatment will take either nerandomilast or a placebo twice daily…

This early-stage study tests a new treatment called CABA-201 for people with systemic sclerosis (scleroderma), a disease that causes hardening of the skin and can damage organs. The treatment uses a patient's own immune cells, modified to target and destroy faulty B cells that dr…

This trial tests whether a newer type of CT scan, called photon-counting CT, can help doctors identify idiopathic pulmonary fibrosis (IPF) more accurately than the standard high-resolution CT scan. The study will enroll 156 adults with interstitial lung disease who need a multidi…

This study tests a drug called nerandomilast in 80 people aged 40+ who have early lung changes and a family history of pulmonary fibrosis. Participants take either the drug or a placebo twice daily for up to 3 years. Doctors monitor lung function and scans to see if the drug slow…

This study follows 4,000 people with interstitial lung disease (including conditions like pulmonary fibrosis and sarcoidosis) to understand how the disease naturally changes over time. Researchers will collect medical data and blood samples, and compare them to a healthy control …

This study will enroll 25 adults with interstitial lung disease or COPD to investigate the physical origins of ultrasound artifacts seen in lung scans. Researchers will compare ultrasound findings with CT scans and wearable sensor data to understand what these artifacts really me…

This study is for children and adults with interstitial lung disease, a group of conditions that scar the lungs and make breathing hard. Researchers will follow 3000 patients and their relatives for up to 10 years, collecting medical data and genetic information. The goal is to l…

This study is building a large collection of blood, tissue, and fluid samples from 7,000 people with lung cancer, other chest diseases, or lung transplants. The goal is to help researchers learn more about what causes these diseases, how to find them early, and how to treat them …

This study will use advanced CT scans to look at both the lungs and heart in people with interstitial lung disease (ILD). The goal is to find early signs of heart problems, which are common but often missed until serious. Researchers hope to create better ways to predict and mana…