BIPOLAR 1 DISORDER

This study tests a long-acting injection of cariprazine given once a month under the skin. It is for people with schizophrenia, bipolar I disorder, or major depressive disorder who are stable on other medications. The goal is to see if the injection is safe, tolerable, and effect…

This study tests whether clozapine, a powerful antipsychotic, works better than risperidone for people with schizophrenia, schizoaffective disorder, or bipolar 1 disorder who have a specific brain-based 'biotype.' About 320 adults will be randomly assigned to receive either cloza…

This study tests an experimental drug called RAP-219 for people with bipolar I disorder who are currently having a manic episode (feeling extremely high, energetic, or irritable). About 250 adults will receive either RAP-219 or a placebo to see if the drug safely reduces manic sy…

This study looks at whether wearing blue-blocking glasses can reduce manic symptoms in people with bipolar 1 disorder who are currently hospitalized for a manic episode. Over 7 days, 25 adult participants will wear the glasses and report on mood, sleep, and overall function. The …

This study looks at 320 people who recently developed psychosis (like schizophrenia or bipolar I) to see if brain scans, eye-tracking, and genetics can predict who will get better with treatment. Participants attend four visits over a year, providing DNA, EEG, and MRI data. The g…