X-linked mixed hearing loss with perilymphatic gusher
MONDO:0010576X-linked mixed deafness with perilymphatic gusher, also known as X-linked deafness type 2, is a rare form of non-syndromic genetic deafnesss affecting males and characterized by pathognomonic inner ear anomalies and conductive and profound sensorineural hearing loss. The inner ear anomalies are described as dilatation of the internal auditory meatus and fistulous connection between the cochlear basal turn and internal auditory canal resulting in perilympatic gusher on attempted mobilization of a fixed stapes. Obligate female carriers may suffer from mild to moderate hearing loss.
Also known as: central hearing loss, high frequency deafness, high frequency hearing loss, high-frequency hearing loss, perceptive deafness, perceptive hearing loss, perceptive hearing loss or deafness, sensorineural deafness
34 clinical trials for this condition and its sub-types, 32 tagged with X-linked mixed hearing loss with perilymphatic gusher itself.
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Can stem cells restore hearing? early trial aims to find out
Disease control By invitation onlyThis early-phase study is testing whether stem cell therapies and experimental drugs can help repair inner ear damage in people with hearing loss or tinnitus. Researchers will monitor 120 adults over time using hearing tests and symptom surveys. The goal is to see if these regene…
Early phase 1 • Sponsor: Truway Health, Inc. • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Revolutionary fully implanted hearing device tested in adults
Disease control OngoingThis study tests a fully implanted cochlear implant called Acclaim CI in 56 adults with severe to profound hearing loss. The goal is to see if it helps them hear words better than before and to check for any medical problems. Participants get the implant and are followed for up t…
Sponsor: Envoy Medical Corporation • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Can smarter hearing aids keep aging brains sharp?
Disease control OngoingThis study tests whether a personalized, data-driven hearing rehabilitation program can improve hearing, thinking, and quality of life in older adults with mild to moderate hearing loss. Two hundred first-time hearing aid users will be randomly assigned to either the new personal…
Sponsor: Kuopio University Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:11 UTC
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Brain-Training games aim to boost hearing in crowds
Knowledge-focused CancelledThis study planned to test whether playing specially designed video games at home could improve the ability of older adults with high-frequency hearing loss to understand speech in noisy environments. Participants would have played either an immersive audiomotor game or an audito…
Sponsor: Massachusetts Eye and Ear Infirmary • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC