Well-differentiated liposarcoma
MONDO:0005103A locally aggressive malignant neoplasm composed of mature adipocytes showing cell size variation and nuclear atypia. It is often associated with the presence of hyperchromatic multinucleated stromal cells, and varying numbers of lipoblasts. There are three histologic subtypes, sclerosing, inflammatory, and spindle cell liposarcoma. These tumors do not usually metastasize unless they undergo dedifferentiation.
Also known as: atypical lipomatous tumor, atypical lipomatous tumour, ALT, WDLS, atypical lipoma, well differentiated liposarcoma, well differentiated liposarcoma of deep soft tissue, well-differentiated liposarcoma
2819 clinical trials for this condition and its sub-types, 5 tagged with Well-differentiated liposarcoma itself.
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Sub-types of Well-differentiated liposarcoma
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Inflammatory liposarcoma 0 trials
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Sclerosing liposarcoma 0 trials
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Spindle cell liposarcoma 0 trials
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New combo therapy shows promise for rare cancer
Disease control OngoingThis study tests whether combining two drugs, palbociclib and INCMGA00012, is safe and effective for people with advanced liposarcoma, a rare cancer of fat cells. About 42 participants with tumors that cannot be removed by surgery or have spread will receive the combination. The …
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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New drug BTX-A51 tested in rare sarcomas
Disease control OngoingThis early study tests an oral drug called BTX-A51 in 24 people with advanced liposarcoma (a type of fat tissue cancer) that has spread or come back. The main goal is to see if the drug is safe and tolerable at different doses. It focuses on specific genetic subtypes: MDM2-amplif…
Phase 1 • Sponsor: Michael Wagner, MD • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC