Visceral leishmaniasis
MONDO:0005445A severe form of leishmaniasis characterized by irregular bouts of fever, substantial weight loss, swelling of the spleen and liver, and anemia (which may be serious). If left untreated it may lead to death. Two species of Leishmania are known to give rise to the visceral form of the disease. The species commonly found in East Africa and the Indian subcontinent is L. donovani and the species found in Europe, North Africa, and Latin America is L. infantum, also known as L. chagasi.
Also known as: kala-azar, viscus leishmaniasis, kala-azar susceptibility, kala-azar, susceptibility to
15 clinical trials for this condition and its sub-types, 14 tagged with Visceral leishmaniasis itself.
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Scientists study leishmania infections to improve diagnosis and care
Knowledge-focused Recruiting nowThis study looks at how leishmaniasis infections progress and respond to treatment. It involves up to 289 people aged 3 to 100 with known or suspected leishmaniasis. Researchers will collect blood and tissue samples to learn more about the disease and test different treatments. T…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC
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Can leishmania antigens trigger a protective immune response?
Knowledge-focused Recruiting nowThis study investigates whether six specific Leishmania antigens can activate T-cells in blood and tissue samples from patients with visceral and cutaneous leishmaniasis. Researchers will compare responses before and after treatment, and against healthy volunteers, to see if thes…
Sponsor: Institute of Tropical Medicine, Belgium • Aim: Knowledge-focused
Last updated Aug 26, 2026 00:00 UTC
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New study aims to speed up leishmaniasis diagnosis in kids
Knowledge-focused Recruiting nowThis study tracks 200 children in Italy with leishmaniasis, a parasitic infection that can affect the skin or internal organs. Researchers will look at how quickly the disease is diagnosed and treated, and how that affects recovery, relapse, and death rates. The goal is to identi…
Sponsor: Meyer Children's Hospital IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Scientists probe hidden causes of deadly parasite relapse in HIV patients
Knowledge-focused Recruiting nowThis study looks at 20 adults in Ethiopia who have both HIV and visceral leishmaniasis (a serious parasitic disease). Researchers want to find out why the parasite keeps coming back in some patients and how to better monitor treatment. Participants provide samples and attend foll…
Sponsor: Institute of Tropical Medicine, Belgium • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC