Vaginal squamous cell carcinoma

MONDO:0006490

A squamous cell carcinoma arising from the vagina. Human papillomavirus infection is associated with the development of vaginal intraepithelial neoplasia and invasive squamous cell carcinoma. Signs and symptoms include painless bleeding, postcoital bleeding, and urinary tract symptoms. Morphologically it resembles squamous cell carcinomas in other anatomic sites. Radiation therapy is the preferred treatment for most cases. The prognosis is related to the stage of the disease.

Also known as: carcinoma of vagina squamous cell, epidermoid carcinoma of the vagina, epidermoid carcinoma of vagina, epidermoid cell carcinoma of the vagina, epidermoid cell carcinoma of vagina, squamous cell carcinoma of the vagina, squamous cell carcinoma of vagina, vagina epidermoid carcinoma

2854 clinical trials for this condition and its sub-types, 8 tagged with Vaginal squamous cell carcinoma itself.

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Where it sits in the disease tree

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↑ Squamous cell carcinoma (1774) ↑ Vaginal carcinoma (22) ↑ Vaginal squamous tumor (8)

Including sub-types (2854) Tagged with Vaginal squamous cell carcinoma (8)

Trials to join now! 2 Not yet recruiting 1 Not yet finished but already full! 4 Terminated 1

Can a smart drug shrink rare gynecologic tumors?

Disease control Not yet recruiting

This phase II trial tests whether sacituzumab tirumotecan (Sac-TMT) can shrink tumors in people with advanced or metastatic squamous cell carcinoma of the vagina or vulva. These cancers are rare, and there is no standard second-line treatment. Sac-TMT is an antibody-drug conjugat…

Phase 2 • Sponsor: Latin American Cooperative Oncology Group • Aim: Disease control

Last updated Sep 06, 2026 00:00 UTC

Vaginal squamous cell carcinoma

Where it sits in the disease tree

Can a smart drug shrink rare gynecologic tumors?