Undifferentiated pleomorphic sarcoma
MONDO:0002142An undifferentiated soft tissue sarcoma characterized by the presence of a pleomorphic malignant cellular infiltrate. It is also known as malignant fibrous histiocytoma.
Also known as: MFH, Storiform-pleomorphic MFH, Storiform-pleomorphic fibrous histiocytoma, Storiform-pleomorphic malignant fibrous histiocytoma, UPS, Unclassified Pleomorphic sarcoma (formerly "MFH"), Unclassified Pleomorphic sarcoma (formerly "malignant fibrous histiocytoma"), adult malignant fibrous histiocytoma
2866 clinical trials for this condition and its sub-types, 48 tagged with Undifferentiated pleomorphic sarcoma itself.
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Browse by category →Sub-types of Undifferentiated pleomorphic sarcoma
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New cancer drug BBI-355 trial halted early – what we know
Disease control Stopped earlyThis early-phase trial tested a new oral drug called BBI-355, alone or with other targeted therapies, in people with advanced solid tumors that had extra DNA (oncogene amplifications). The study aimed to find the safest dose and check for side effects. It was terminated early, so…
Phase 1 • Sponsor: Boundless Bio, Inc. • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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Focused ultrasound trial for rare sarcoma halted early
Disease control Stopped earlyThis study tested whether focused ultrasound could partially destroy a rare soft-tissue cancer called undifferentiated pleomorphic sarcoma and boost the body's immune response. Only 5 people were enrolled before the trial was terminated. The main goal was to check safety and see …
Sponsor: Matthew Bucknor • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Experimental drug tested for rare cancer, trial stopped early
Disease control Stopped earlyThis study tested a drug called XmAb23104 in people with advanced sarcoma, a rare cancer. The goal was to see if the drug could shrink tumors and if it was safe. Only 6 people took part before the study was ended early.
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC