Treatment-refractory schizophrenia
MONDO:0005414Schizophrenia which does not respond to commonly used treatments.
Also known as: TRS, refractory schizophrenia, treatment-refractory schizophrenia
96 clinical trials for this condition and its sub-types, 24 tagged with Treatment-refractory schizophrenia itself.
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Brain pacemaker tested for untreatable schizophrenia
Disease control Stopped earlyThis pilot study tested deep brain stimulation (DBS) in 15 people with treatment-resistant schizophrenia who still had severe hallucinations despite medication. The device was placed in a brain area linked to schizophrenia to try to calm symptoms. The study was terminated early, …
Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Tiny study probes why clozapine beats other schizophrenia drugs
Knowledge-focused Stopped earlyThis study aimed to compare the effects of clozapine versus other antipsychotic medications on inflammation in people with treatment-resistant schizophrenia. Researchers measured inflammatory markers like interleukin-6 in a small group of participants. The study was terminated ea…
Phase 4 • Sponsor: Ohio State University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC