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Tonsillar squamous cell carcinoma
MONDO:0006470A squamous cell carcinoma that arises from the mucosal lining of the tonsil and tends to metastasize early to the lymph nodes. It predominantly affects middle aged and elderly patients who have a history of alcohol and tobacco use. Patients may present with tonsillar swelling, sore throat, pain radiating to the ipsilateral ear, or a neck mass.
Also known as: SCC of the tonsil, SCC of tonsil, palatine tonsil squamous cell carcinoma, squamous cell carcinoma of the tonsil, squamous cell carcinoma of tonsil, tonsil SCC, tonsil squamous cell carcinoma, tonsillar SCC
2970 clinical trials for this condition and its sub-types, 4 tagged with Tonsillar squamous cell carcinoma itself.
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Can proton radiation spare tonsil cancer patients from harsh side effects?
Disease control Recruiting nowThis trial tests whether proton therapy causes fewer side effects than standard photon radiation in people with early tonsil cancer. About 100 patients will be randomly assigned to receive one of the two radiation types, both aimed at curing the cancer. Researchers will track acu…
Sponsor: Lund University Hospital • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Promising cocktail aims to shrink tonsil tumors before surgery
Disease control Recruiting nowThis pilot study is testing whether a combination of two targeted drugs (nimotuzumab and toripalimab) plus standard chemotherapy can shrink locally advanced tonsillar cancer before surgery. Ten adults with resectable tumors will receive the treatment for 2-4 cycles, then have sur…
Phase 2 • Sponsor: Tang-Du Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Extra 6-Minute MRI scan may guide robotic tonsil cancer surgery
Knowledge-focused Recruiting nowThis study is testing whether adding a short MRI scan before surgery can help predict if all cancer will be removed during transoral robotic surgery (TORS) for HPV-positive tonsil cancer. About 30 adults will get a standard MRI with two extra sequences that take only 6 minutes. D…
Sponsor: Case Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC