Thyroid gland undifferentiated (anaplastic) carcinoma
MONDO:0006468A primary carcinoma of the thyroid gland composed of undifferentiated cells. The malignant cells demonstrate evidence of epithelial differentiation, either by immunohistochemistry or electron microscopic studies. Microscopically, in the majority of cases there is a mixture of spindle, epithelioid, and giant cells. The vast majority of the patients present with a rapidly enlarging neck mass. The clinical course is usually aggressive.
Also known as: Dedifferentiated thyroid gland carcinoma, anaplastic carcinoma of the thyroid, anaplastic carcinoma of the thyroid gland, anaplastic carcinoma of thyroid, anaplastic carcinoma of thyroid gland, anaplastic thyroid cancer, anaplastic thyroid carcinoma, anaplastic thyroid gland carcinoma
2787 clinical trials for this condition and its sub-types, 35 tagged with Thyroid gland undifferentiated (anaplastic) carcinoma itself.
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Experimental combo targets deadly thyroid cancer
Disease control Stopped earlyThis phase 2 trial tested whether the immunotherapy drug pembrolizumab, given after radiation therapy, could help control anaplastic thyroid cancer that is still in the neck. Only 6 patients were enrolled before the study was stopped early. The goal was to see how long patients l…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Immunotherapy combo tested for tough thyroid cancers
Disease control Stopped earlyThis phase II trial tested two immunotherapy drugs, durvalumab and tremelimumab, in 79 patients with advanced thyroid cancer that had progressed despite treatment. The goal was to see if the combination could slow or stop cancer growth. The study was terminated early, so the full…
Phase 2 • Sponsor: Grupo Espanol de Tumores Neuroendocrinos • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC