Thrombotic thrombocytopenic purpura
MONDO:0018896Thrombotic thrombocytopenic purpura (TTP) is an aggressive and life-threatening form of thrombotic microangiopathy (TMA) characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and organ failure of variable severity and is comprised of congenital TTP and acquired TTP.
Also known as: Moschcowitz disease, Moschowitz disease, TTP
32 clinical trials for this condition and its sub-types, 15 tagged with Thrombotic thrombocytopenic purpura itself.
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Browse by category →Sub-types of Thrombotic thrombocytopenic purpura
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New hope for rare blood clotting disorder? daratumumab under study
Disease control Recruiting nowThis study is collecting information from 40 patients with a rare blood disorder called immune-mediated thrombotic thrombocytopenic purpura (iTTP) who have been treated with daratumumab. The goal is to see how well daratumumab works and how safe it is for patients whose disease d…
Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New drug ADZYNMA tracked for safety in rare blood disorder
Disease control Recruiting nowThis study monitors 40 people in Japan with congenital thrombotic thrombocytopenic purpura (cTTP) who are receiving ADZYNMA (recombinant ADAMTS13) as part of their routine care. Researchers will track side effects and check if the drug improves platelet counts and ADAMTS13 activi…
Sponsor: Takeda • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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New study tracks safety of adzynma for rare blood clot disorder
Knowledge-focused Recruiting nowThis study looks at the real-world safety of Adzynma, a lab-made protein, in people with congenital thrombotic thrombocytopenic purpura (cTTP), a rare inherited blood disorder. Researchers will review medical records of about 50 children and adults to see how many develop allergi…
Sponsor: Takeda • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Scientists hunt for relapse clues in TTP Patients' immune cells
Knowledge-focused Recruiting nowThis study looks at blood samples from 44 people with thrombotic thrombocytopenic purpura (TTP) to understand how certain immune cells (B and T lymphocytes) react to the ADAMTS13 protein during different stages of the disease. The goal is to find early warning signs that could pr…
Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Massive study aims to unlock secrets of rare blood disorder
Knowledge-focused Recruiting nowThis study reviews medical records from over 1,200 people with immune thrombotic thrombocytopenic purpura (iTTP), a rare and life-threatening blood disorder. The goal is to understand long-term health problems, such as heart disease and thinking issues, that survivors face. By an…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC