Thiel-Behnke corneal dystrophy

MONDO:0011185

Thiel-Behnke corneal dystrophy (TBCD) is a rare form of superficial corneal dystrophy characterized by sub-epithelial honeycomb-shaped corneal opacities in the superficial cornea, and progressive visual impairment.

Also known as: TBCD, Thiel-Behnke corneal dystrophy, Waardenburg-Jonker corneal dystrophy, anterior limiting membrane dystrophy type 2, anterior limiting membrane dystrophy type II, corneal dystrophy of Bowman layer type 2, corneal dystrophy of Bowman layer type II, curly fiber corneal dystrophy

8 clinical trials for this condition and its sub-types, 1 tagged with Thiel-Behnke corneal dystrophy itself.

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Part of

↑ Superficial corneal dystrophy (7) ↑ Epithelial-stromal TGFBI dystrophy (3)

Including sub-types (8) Tagged with Thiel-Behnke corneal dystrophy (1)

Not yet recruiting 1

Can a single Gene-Editing injection stop a blinding corneal disease?

Cure Not yet recruiting

This trial tests a single injection of GEB-101, a gene-editing treatment, directly into the cornea of people with TGFBI-related corneal dystrophy, a hereditary condition that causes progressive vision loss. The study aims to see if the treatment is safe and whether it can slow or…

Phase 1/2 • Sponsor: GenEditBio Limited • Aim: Cure

Last updated Sep 12, 2026 00:00 UTC

Thiel-Behnke corneal dystrophy

Where it sits in the disease tree

Can a single Gene-Editing injection stop a blinding corneal disease?