Tenosynovial giant cell tumor
MONDO:0002522A tumor usually arising in the synovium of joints, bursa or tendon sheath. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. According to the growth pattern, it is classified as localized or diffuse.
Also known as: fibrous histiocytoma of tendon sheath, giant cell neoplasm of Tenosynovium, giant cell neoplasm of tendon sheath, giant cell neoplasm of the Tenosynovium, giant cell tumor of Tenosynovium, giant cell tumor of tendon sheath, giant cell tumor of the Tenosynovium, giant cell tumour of the Tenosynovium
1470 clinical trials for this condition and its sub-types, 12 tagged with Tenosynovial giant cell tumor itself.
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Sub-types of Tenosynovial giant cell tumor
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New drug hope for rare joint tumor patients who Can't have surgery
Disease control CompletedThis study tested a drug called pexidartinib (TURALIO) in 9 Japanese adults with tenosynovial giant cell tumor (TGCT), a rare, non-cancerous growth in the joints that causes pain and limits movement. The goal was to see if the drug is safe and can shrink tumors in people whose tu…
Phase 2 • Sponsor: Daiichi Sankyo Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 14:03 UTC
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Leukemia drug shows promise against rare joint tumors
Disease control CompletedThis study tested nilotinib, a drug originally used for leukemia, in 17 patients with relapsed or metastatic pigmented villonodular synovitis (PVNS) or related giant cell tumors. The goal was to see if the drug could stop tumor growth or improve symptoms. Results focused on how l…
Phase 2 • Sponsor: Andrew J. Wagner, MD, PhD • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC