T-cell large granular lymphocyte leukemia

MONDO:0019469

T-cell large granular lymphocyte leukemia (T-cell LGL leukemia) is a lymphoproliferative malignancy that arises from the mature T-cell (CD3+) lineage.

Also known as: LGLL, T gamma lymphoproliferative disorder, T-LGL, T-LGL leukaemia, T-LGL leukemia, T-cell LGL leukaemia, T-cell LGL leukemia, T-cell large gran. lymph. leuk.

1962 clinical trials for this condition and its sub-types, 18 tagged with T-cell large granular lymphocyte leukemia itself.

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Where it sits in the disease tree

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↑ Immune system disorder (12959) ↑ Lymphoid leukemia (1360) ↑ Chronic leukemia (747) ↑ Mature T-cell and NK-cell non-Hodgkin lymphoma (240)

Including sub-types (1962) Tagged with T-cell large granular lymphocyte leukemia (18)

Trials to join now! 7 Not yet recruiting 2 Not yet finished but already full! 5 Completed 3 Terminated 1

Experimental drug shows early promise in rare leukemia study

Disease control Stopped early

This early-phase study tested the drug siltuximab in 6 adults with large granular lymphocytic leukemia (LGLL), a rare blood cancer. The goal was to see if the drug is safe and can shrink or control the disease. The study was terminated early, so results are limited.

Early phase 1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control

Last updated Jun 27, 2026 09:02 UTC

T-cell large granular lymphocyte leukemia

Where it sits in the disease tree

Experimental drug shows early promise in rare leukemia study