Supravalvular aortic stenosis
MONDO:0008504SupraValvar Aortic Stenosis (SVAS) is characterized by the narrowing of the aorta lumen (close to its origin) or other arteries (branch pulmonary arteries, coronary arteries). This narrowing of the aorta or pulmonary branches may impede blood flow, resulting in heart murmur and ventricular hypertrophy (in case of aorta involvement). The narrowing results from a thickening of the artery wall, which is not related to atherosclerosis.
Also known as: SVAS, supravalvar aortic stenosis, supravalvular aortic stenosis, supravalvular aortic stenosis (disease), aortic supravalvular stenosis, supravalvar aortic stenosis, Eisenberg type
61 clinical trials for this condition and its sub-types, 3 tagged with Supravalvular aortic stenosis itself.
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NIH study probes hidden impact of stiff arteries in rare genetic condition
Knowledge-focused CompletedThis study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Scientists launch DNA bank to unlock secrets of rare heart and genetic conditions
Knowledge-focused CompletedThis study collected DNA, tissue, and medical history from 305 people with Williams syndrome or supravalvar aortic stenosis (SVAS), as well as their family members and healthy volunteers. The goal was to create a resource for future research to understand why symptoms vary so muc…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Aug 30, 2026 00:00 UTC