Spinocerebellar ataxia type 1
MONDO:0008119Spinocerebellar ataxia type 1 (SCA1) is a subtype of type I autosomal dominant cerebellar ataxia (ADCA type I) characterized by dysarthria, writing difficulties, limb ataxia, and commonly nystagmus and saccadic abnormalities.
Also known as: ATXN1 autosomal dominant cerebellar ataxia type I, SCA1, Sca1, autosomal dominant cerebellar ataxia type I caused by mutation in ATXN1, spinocerebellar ataxia type 1, Menzel type OPCA, OPCA 1, OPCA 4
29 clinical trials for this condition and its sub-types, 10 tagged with Spinocerebellar ataxia type 1 itself.
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Can a single molecule quiet the genetic chaos behind three brain diseases?
Disease control Recruiting nowThis first-in-human trial is testing an experimental drug called VO659 in people with spinocerebellar ataxia type 1, type 3, or Huntington's disease. The drug is designed to target the genetic repeats that cause these conditions, potentially slowing their progression. The study a…
Phase 1/2 • Sponsor: Vico Therapeutics B. V. • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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Can we predict how genetic ataxias progress?
Knowledge-focused Recruiting nowThis study follows people with several types of spinocerebellar ataxia (SCA) — rare genetic diseases that cause balance, coordination, and speech problems — to learn how these conditions change over time. Researchers will collect blood samples, perform neurological exams, and use…
Sponsor: Lauren Moore • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC
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New study sheds light on vision loss in rare genetic brain disorders
Knowledge-focused Recruiting nowThis study looks at how spinocerebellar ataxia (SCA) affects the eyes and vision. Researchers will examine 60 adults with SCA types 1, 2, 3, or 27B, including those with early symptoms and those who are not yet symptomatic. The goal is to measure vision changes and eye damage usi…
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC