Sinus histiocytosis with massive lymphadenopathy
MONDO:0006412A rare disorder of unknown etiology characterized by distention of the lymph node sinuses and sinusoidal histiocytic infiltration. The histiocytes characteristically contain ingested lymphocytes. Patients present with cervical lymphadenopathy, fever, leukocytosis, and hypergammaglobulinemia. It can affect extranodal sites, including skin, bones, and the respiratory tract. It usually regresses spontaneously.
Also known as: Destombes-RosaC/-Dorfman disease, Destombes-Rosaï-Dorfman disease, RDD, RosaC/-Dorfman-Destombes disease, Rosai-Dorfman Disease, Rosai-Dorfman disease, Rosaï-Dorfman-Destombes disease, SHML
16 clinical trials for this condition and its sub-types, 11 tagged with Sinus histiocytosis with massive lymphadenopathy itself.
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Browse by category →Sub-types of Sinus histiocytosis with massive lymphadenopathy
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H syndrome 0 trials
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Scientists hunt for genetic clues in rare blood disorders
Knowledge-focused PausedThis study looks at the genetic makeup of rare blood diseases like Castleman disease and Langerhans cell histiocytosis. Researchers will analyze blood or tissue samples from 135 participants to find genetic changes that could be targeted by existing or experimental therapies. The…
Sponsor: Case Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Aug 08, 2026 00:03 UTC
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Rare disease study probes hidden brain effects
Knowledge-focused OngoingThis study looks at how histiocytosis—a group of rare disorders—may affect memory, thinking, and brain structure. Researchers will test 13 adults with these conditions using thinking tasks and MRI scans. The goal is to better understand brain changes, not to provide treatment.…
Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC