Sezary syndrome
MONDO:0017844Sezary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma characterized by a triad of erythroderma, lymphadenopathy and circulating atypical lymphocytes (Sezary cells).
Also known as: CTCL / Sezary syndrome, SC)zary syndrome, Sezary disease, Sezary lymphoma, Sezary syndrome, Sezary's disease, Sheehan Syndrome, Sézary lymphoma
3128 clinical trials for this condition and its sub-types, 45 tagged with Sezary syndrome itself.
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New pill targets immune signals in rare lymphomas
Disease control Not yet recruitingThis pilot study tests an oral drug called golidocitinib in people with two rare blood cancers: mycosis fungoides/Sézary syndrome (a type of skin lymphoma) and T-cell large granular lymphocytic leukemia. The drug blocks a protein called JAK1, which is involved in cancer cell grow…
Phase 2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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New drug cocktail aims to tackle tough skin cancer
Disease control Not yet recruitingThis study tests a combination of four chemotherapy drugs (aclarubicin, cyclophosphamide, vincristine, and prednisone) in people with cutaneous T-cell lymphoma that has come back or not responded to prior treatment. The trial has two phases: first, finding the safest dose of acla…
Phase 1/2 • Sponsor: Shanghai Jiao Tong University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New antibody targets Hard-to-Treat skin cancer in first human trial
Disease control Not yet recruitingThis early-phase trial tests a new drug called DT-7012 for people with a rare type of skin lymphoma (CTCL) that has not responded to other treatments. The drug is an antibody designed to find and kill cancer cells in the skin and boost the immune system. About 30 adults with adva…
Early phase 1 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Rare skin disease patients develop even rarer lymphoma – scientists investigate why
Knowledge-focused Not yet recruitingThis study looks at the blood immune cells of 10 adults with a rare inherited skin condition called NIPAL4 ichthyosis. Researchers want to understand why three patients with this skin disease also developed a very rare lymphoma (Sezary syndrome). By describing the normal immune c…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC