Septooptic dysplasia

MONDO:0008428

Septooptic dysplasia (SOD) is a clinically heterogeneous disorder characterized by the classical triad of optic nerve hypoplasia, pituitary hormone abnormalities and midline brain defects.

Also known as: De Morsier syndrome, SOD, septo-optic dysplasia, septo-optic dysplasia sequence, septooptic dysplasia, Growth hormone deficiency with pituitary anomalies, hypopituitarism and septooptic 'dysplasia', pituitary hormone deficiency, combined, 5

2 clinical trials for this condition and its sub-types, 1 tagged with Septooptic dysplasia itself.

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Where it sits in the disease tree

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Part of

↑ Syndromic disease (7158) ↑ Autosomal genetic disease (1670) ↑ Combined pituitary hormone deficiencies, genetic form (42)

Sub-types of Septooptic dysplasia

Congenital absence of septum pellucidum 0 trials
Pagon stephan syndrome 0 trials

Including sub-types (2) Tagged with Septooptic dysplasia (1)

Trials to join now! 1

Hope for hypothalamic obesity: daily shot targets weight and hunger

Disease control Recruiting now

This phase 3 trial tests whether a daily injection of setmelanotide can help people aged 4 and older with hypothalamic obesity lose weight and feel less hungry. Participants will receive either the drug or a placebo for 26 weeks. The study aims to see if the treatment leads to me…

Phase 3 • Sponsor: Rhythm Pharmaceuticals, Inc. • Aim: Disease control

Last updated Jun 27, 2026 09:04 UTC

Septooptic dysplasia

Where it sits in the disease tree

Hope for hypothalamic obesity: daily shot targets weight and hunger