Seminoma

This phase 2 trial explores whether some people with stage II seminoma, a type of testicular cancer, can receive less intensive treatment after surgery. All participants first receive one cycle of EP chemotherapy. Those whose PET scan is negative are then randomly assigned to eit…

This trial tests whether combining two imaging techniques—a radioactive tracer and a fluorescent dye—can better identify sentinel lymph nodes in men with testicular seminoma. The goal is to see if this approach can accurately show whether cancer has spread, potentially allowing s…

This phase 3 trial studies two approaches for germ cell tumors. For low-risk patients whose tumor has been removed, doctors will monitor them closely instead of giving chemotherapy. For standard-risk patients whose cancer has spread, the trial compares two chemotherapy drugs—carb…

This study tests whether robotic surgery can be the first treatment for stage IIA/B testicular seminoma, instead of chemotherapy or radiation. The surgery removes lymph nodes in the abdomen using a robot. The goal is to see if it prevents cancer from coming back. The trial will e…

This study tests whether taking two drugs (zanzalintinib and oral etoposide) after high-dose chemotherapy can help keep relapsed germ cell tumors from growing. About 38 adults whose cancer has not been cured by standard treatments will participate. The goal is to see if this comb…

This phase II trial is testing whether robot-assisted surgery to remove lymph nodes in the abdomen can help predict and prevent cancer recurrence in men with stage II seminoma. About 60 participants will undergo the procedure, with the option of one round of chemotherapy afterwar…

This study tests a new, less invasive way to check if testicular cancer has spread. Doctors inject a dye into the testicle, then use a robot to find and remove the first lymph node that drains the tumor. The goal is to see if this method is accurate enough to replace more extensi…

This early-stage trial tests whether adding Pedmark to standard cisplatin chemotherapy can prevent hearing loss in men with metastatic testicular cancer. About 80% of patients currently develop hearing damage from cisplatin. Pedmark works by neutralizing harmful molecules that ca…

This study is looking for certain cells in the blood of people with 9 types of advanced cancers that have spread. Researchers will take one blood sample from each of 450 participants before they start a new treatment. They will use two different lab methods to see if they can fin…

This study looks at men with good-prognosis metastatic testicular cancer to see if surgery (RPLND) leads to a better quality of life than chemotherapy. About 160 men over 18 will be followed to measure side effects and daily well-being. The goal is to find which treatment causes …

This study looks at whether follow-up care for people with rare tumors can be done just as well by a nurse remotely as by a doctor in person. About 88 adults recently diagnosed with a rare tumor will be randomly assigned to either in-person doctor visits or remote nurse check-ins…

This study is testing whether giving less treatment (de-escalation) to men with stage II seminoma testicular cancer is safe and improves quality of life. Researchers will enroll 30 men at two UK hospitals to see if patients are willing to join and how their cancer and well-being …