Scleroderma

MONDO:0019340

Scleroderma is a rare autoimmune connective tissue disorder characterized by abnormal hardening of the skin and, sometimes, other organs. It is classified into two main forms: localized scleroderma and systemic sclerosis (SSc), the latter comprising three subsets; diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc) and limited SSc (lSSc).

Also known as: scleroderma, scleroderma (disease)

339 clinical trials for this condition and its sub-types, 47 tagged with Scleroderma itself.

Follow this condition to get notified about new trials

Where it sits in the disease tree

Browse by category →

Part of

↑ Autoimmune disease (4033) ↑ Rheumatic disorder (1792)

Sub-types of Scleroderma

Systemic sclerosis 261 trials · 295 incl. sub-types
6 sub-types
- Diffuse scleroderma 82 trials
- Diffuse cutaneous systemic sclerosis 30 trials
- Pulmonary systemic sclerosis 27 trials
- Limited cutaneous systemic sclerosis 2 trials Sub-types →
- Limited systemic sclerosis 0 trials
- Scleroderma, familial progressive 0 trials
Localized scleroderma 14 trials · 15 incl. sub-types
2 sub-types
- Linear scleroderma 1 trial
- Lipodermatosclerosis 1 trial
Neonatal scleroderma 0 trials

Most studied deeper sub-types

CREST syndrome (0)

Including sub-types (339) Tagged with Scleroderma (47)

Trials to join now! 23 Not yet recruiting 2 Not yet finished but already full! 6 Completed 15 Terminated 1

Laser hope for scars and scleroderma fizzles in tiny trial

Symptom relief Stopped early

This study tested whether a special laser could improve scars and skin hardening from scleroderma. Only 6 people took part, and the study was stopped early. Researchers measured scar changes using a standard scale, but the small size and early termination mean we cannot draw firm…

Sponsor: Massachusetts General Hospital • Aim: Symptom relief

Last updated Jun 27, 2026 12:03 UTC

Scleroderma

Where it sits in the disease tree

Most studied deeper sub-types

Laser hope for scars and scleroderma fizzles in tiny trial