Schnitzler syndrome

MONDO:0018304

A rare, underdiagnosed disorder in adults characterized by recurrent febrile rash, bone and/or joint pain, enlarged lymph nodes, fatigue, a monoclonal IgM component, leukocytosis and systemic inflammatory response.

Also known as: chronic urticaria with gammopathy, chronic urticaria with macroglobulinemia, chronic urticaria with gammapathy

11 clinical trials for this condition and its sub-types, 1 tagged with Schnitzler syndrome itself.

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Where it sits in the disease tree

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↑ Autoinflammatory syndrome (207)

Including sub-types (11) Tagged with Schnitzler syndrome (1)

Trials to join now! 1

New study tests ilaris to tame rare inflammatory disease

Disease control Recruiting now

This study looks at how well and how safely the drug Ilaris (canakinumab) works for people with Schnitzler's syndrome, a rare condition that causes hives, fever, joint pain, and fatigue. About 5 participants will receive the drug and be monitored for up to 48 weeks. The goal is t…

Sponsor: Novartis Pharmaceuticals • Aim: Disease control

Last updated Sep 05, 2026 00:00 UTC

Schnitzler syndrome

Where it sits in the disease tree

New study tests ilaris to tame rare inflammatory disease