SAPHO syndrome
MONDO:0019266SAPHO syndrome (acronym for Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is an auto-inflammatory disease, mainly characterized by the association of neutrophilic cutaneous involvement and chronic osteomyelitis.
Also known as: PPHS, Pustulo-psoriatic hyperostotic Spondyloarthritis, synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome, synovitis-acne-pustulosis-hyperostosis-osteitis syndrome, acquired hyperostosis syndrome, synovitis acne pustulosis hyperostosis osteitis, synovitis, acne, Pustlosis, hyperostosis, and osteomyelitis
13 clinical trials for this condition and its sub-types, 3 tagged with SAPHO syndrome itself.
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Hope for rare bone and skin condition: new drug trial launches
Symptom relief Recruiting nowThis study tests whether etanercept, a drug that blocks inflammation, can reduce pain and disease activity in adults with SAPHO syndrome—a rare condition affecting bones, joints, and skin. Participants must have tried standard treatments like NSAIDs without enough relief. The tri…
Phase 2/3 • Sponsor: National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Scientists hunt for genetic clues to rare bone and skin disease
Knowledge-focused Recruiting nowThis study aims to uncover the genetic and immune factors behind SAPHO syndrome, a rare chronic condition causing bone inflammation and skin issues. Researchers will collect DNA and cells from 100 adults diagnosed with SAPHO to compare their genetic makeup with the general popula…
Sponsor: Fondation Hôpital Saint-Joseph • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC