Rheumatic fever
MONDO:0017767A post-bacterial multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.
Also known as: ARF, acute rheumatic fever, inflammatory rheumatism
52 clinical trials for this condition and its sub-types, 17 tagged with Rheumatic fever itself.
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Can two existing drugs stop rheumatic fever from scarring young hearts?
Disease control Not yet recruitingResearchers are running a Phase 3 trial to see whether hydroxychloroquine or corticosteroids can reduce heart valve damage in children and young people with acute rheumatic fever. The trial enrolls about 600 participants aged 4 to 25 who are hospitalized with confirmed valve infl…
Phase 3 • Sponsor: Starship Child Health, Te Toka Tumai Auckland • Aim: Disease control
Last updated Sep 21, 2026 17:00 UTC
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Could a monthly pill replace painful penicillin shots for rheumatic heart disease?
Disease control Not yet recruitingThis study will test if taking oral azithromycin pills for three days each month works as well as getting a monthly penicillin shot to prevent rheumatic heart disease from getting worse. The trial plans to enroll 474 Nigerian secondary school students aged 10-18 with mild or mode…
Sponsor: Ladoke Akintola University of Technology, Ogbomoso, Nigeria • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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New study aims to unravel mysteries of common inflammatory condition in older adults
Knowledge-focused Not yet recruitingThis study will follow 400 people recently diagnosed with polymyalgia rheumatica, a condition causing shoulder and hip pain. Researchers will track symptoms, treatments, and outcomes over 5 years to better understand the disease and improve diagnosis. Participants will provide bl…
Sponsor: University Hospital, Brest • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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New study looks at how painkiller works in rheumatic pain
Knowledge-focused Not yet recruitingThis study will examine how the painkiller nefopam works in 24 adults hospitalized with acute rheumatic pain. Researchers will measure how the drug is processed in the body, including its peak levels and how long it stays active. The goal is to better understand the drug's effect…
Phase 4 • Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC